population pharmacokinetics of oral cyclosporin in iranian bone marrow transplant patients: comparison of different absorption models

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Effect of hepatic dysfunction on oral cyclosporin pharmacokinetics in marrow transplant patients.

The effect of hepatic dysfunction, defined as abnormal serum bilirubin level, on oral cyclosporin (CSP) pharmacokinetics was examined in 28 marrow transplant patients who received CSP for prophylaxis of graft-v-host disease. Serum CSP concentrations were measured by radioimmunoassay. Forty-one concentration-time courses were studied, divided among patients with no (less than 1.2 mg/dL), mild (1...

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عنوان ژورنال:
research in pharmaceutical sciences

جلد ۷، شماره ۵، صفحات ۰-۰

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